Sleep Research Using Drosophila

CD BioSciences is devoted to developing the breadth and depth of Drosophila's applications as a model organism, and advancing fundamental neuroscience research by means of interdisciplinary and cross-disciplinary approaches. We provide advanced and comprehensive research solutions to assist our clients. We look forward to working with you.

Introduction

From invertebrates to humans, sleep is not only critical to all aspects of brain function, but is closely linked to many different biological processes. Regular sleep helps repair damage and restore strength. While sleep disorders impair memory, learning and immune function, etc. There have been over 90 sleep-related diseases found in humans, e.g., epilepsy, neuropathy, and depression, etc. Therefore, fundamental research on sleep helps advance the development and technological translation of sleep medicine.

It is very difficult to gain insight into the mechanisms of sleep in mammals because the neural and genetic mechanisms that balance sleep and wakefulness are quite complex. Fortunately, the molecular mechanisms of the circadian rhythm in Drosophila have been intensively studied (The 2017 Nobel Prize in Physiology or Medicine). Relying on previous macroscopic and microscopic findings, Drosophila has the advantage of being a model to study the function and structure of sleep-regulating genes and neural networks.

Extensive Sleep Research Experience

Drosophila, with its optimal balance of functional and structural complexity, is an ideal model for neuroscience research and has great potential for applications in the basic sleep biology, human health and disease. CD BioSciences has the ability to detect thousands of mutant flies simultaneously, and to precisely modulate individual neurons or groups under specific spatio-temporal conditions, significantly reducing the time for clients to screen and discover new targets and genes, moreover accelerating the speed of neural interactions network exploration.

Study of Neural Structure in Sleep

The Drosophila genome and nervous system (almost 10,000 neurons) are relatively simple, but there are numerous regulatory processes and structures that are in a manner similar to those in mammals. Moreover, the sleep regulatory neurons in Drosophila are distributed throughout the whole brain and interacting with other brain activities, making them suitable for studying complex regulatory networks related sleep.

• The central complex, which includes the fan and ellipsoid bodies, receives and processes signals that regulate sleep duration and balance. The firing process of R5 neurons in the ellipsoid body is in a manner similar to the firing of neurons during slow-wave sleep in the mammalian neocortex.
• The mushroom body is composed of 2500 neurons, including dopamine neurons that promote wakefulness and are involved in regulating sleep activity and other higher functions.

Study of Neural Regulation in Sleep

Although the brain structure of Drosophila is relatively simple, it has highly conserved and well-functioning sleep regulation systems, including circadian rhythm and homeostasis regulation, which can be used to study

• Function and brain regulatory activity during different sleep stages
• Brain activity and recovery from sleep deprivation
• The effects of external environmental factors (drugs and diet) on sleep and arousal
• The neural regulation of deep sleep
• Genetic basis of sleep and related disorders
• Influence of circadian rhythms on sleep

Related Services

CD BioSciences Drosophila Center takes advantage of Drosophila's knowledge and technology platform to provide customers with professional sleep and rhythm research solutions. Our purpose is to discover the relationship among sleep behavior, the nervous system and genetics accurately and rapidly, promoting the study and application of sleep disease mechanisms. Our services go beyond this and our techniques go beyond this!

Drosophila Neural Circuits Analysis
Drosophila Genome-Wide Association Study (GWAS)
Drosophila Model Customization
Drosophila Optogenetic Service

Our Advantages

• Professionalism

  We have built a professional Drosophila modeling platform and a team with rich neuroscience experience and cutting-edge knowledge to ensure the scientific direction of the project.

• Personalized Service

  We provide one-stop scientific solutions for metabolism and diseases research to accelerate our clients' research speed.

• Security

  We strictly fulfill the confidentiality agreement to protect the privacy of our clients.

• Effective Price

  We insist on win-win situation, providing the most comprehensive and intimate services at the best price.

CD BioSciences is committed to advancing bioscience technology and basic research using Drosophila. With proven technologies and years of experience in the field of fruit fly, our PhD team conducts one-to-one technical consultancy and mechanistic studies to accelerate our clients' projects. Please feel free to contact us starting your private project customization.

References

• Van Alphen B, et al. (2021). A deep sleep stage in Drosophila with a functional role in waste clearance. Science advances, 7(4), eabc2999.
• Shafer OT, et al. (2021). The regulation of Drosophila sleep. Current Biology, 31(1), R38-R49.

For research use only. Not intended for any clinical use.

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