Recombinant D. melanogaster Protein escargot(esg)

Drosophila melanogaster

esg

esg; flg; CG3758

1-470

Nucleus.

Snail C2H2-type zinc-finger protein family

Transcription factor that can both stimulate and repress transcription. Binds to the consensus DNA sequence 5'-A/GCAGGTG-3'. Regulates cell motility and adhesion during tracheal morphogenesis by stimulating transcription of the DE-cadherin gene shg at branch tips, thereby promoting tracheal tube fusion. Maintains diploidy in imaginal cells by inhibiting the transcription of genes required for endoreplication. Required for development of the genital disk and acts as an intrinsic determinant of wing cell fate. The somatic protein is required for maintenance of male germ cells. Acts with other members of the snail protein family to control embryonic central nervous system development.

KEGG: Dmel_CG3758; STRING: 7227.FBpp0080293; UniGene: Dm.4764

Recombinant Protein

Yeast; E. coli; Baculovirus; Mammalian cell

MHTVEDMLVE KNYSKCPLKK RPVNYQFEAP QNHSNTPNEP QDLCVKKMEI LEENPSEELI NVSDCCEDEG VDVDHTDDEH IEEEDEDVDV DVDSDPNQTQ AAALAAAAAV AAAAAASVVV PTPTYPKYPW NNFHMSPYTA EFYRTINQQG HQILPLRGDL IAPSSPSDSL GSLSPPPHHY LHGRASSVSP PMRSEIIHRP IGVRQHRFLP YPQMPGYPSL GGYTHTHHHH APISPAYSEN SYYSMRSMTP ESSCSSSLPE DLSLKHKNLN LNLNTSQPGE QAAAKTGDMS PETMPNASAK KDKNQPPRYQ CPDCQKSYST FSGLTKHQQF HCPAAEGNQV KKSFSCKDCD KTYVSLGALK MHIRTHTLPC KCNLCGKAFS RPWLLQGHIR THTGEKPFSC QHCHRAFADR SNLRAHLQTH SDIKKYSCTS CSKTFSRMSL LTKHSEGGCP GGSAGSSSSS ELNYAGYAEP

Full Length Protein

>85% (SDS-PAGE)

The following tags are available. N-terminal His-tagged Tag-Free

Lyophilized powder

Tris/PBS-based buffer, 6% Trehalose, pH 8.0

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20 °C/-80 °C. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Delivery time may differ from different purchasing ways or locations, please kindly consult us for specific delivery times.

Store at -20 °C/-80 °C upon receipt, aliquoting is necessary for multiple use.

The shelf life is related to many factors, including storage state, buffer ingredients, storage temperature, and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 °C/-80 °C. The shelf life of lyophilized form is 12 months at -20 °C/-80 °C.

Repeated freezing and thawing are not recommended.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Store working aliquots at 4 °C for up to one week.