Innate Immunity Research Using Drosophila
CD BioSciences is a pioneer and practitioner in Drosophila research, and our goal is to use our knowledge of model organism Drosophila to advance scientific research in various fields such as Biology, Chemistry, Medicine, Environment, and Agriculture, etc. With our core technology and advanced platform, we hope to collaborate with research scholars around the world to use Drosophila as a breakthrough or starting point to help you achieve success in your research projects.
Introduction
The innate immune system, also called nonspecific immunity, is the body's first line of defense, responding in a similar and conservative manner to all bacteria, viruses, or other foreign agents. The innate immune system includes mucosal protection, as well as cellular and protein defenses. The skin and mucous membranes form a physical barrier against pathogens, and immune factors in humor defend against bacterial and viral invasion. When pathogens enter the body through the mucous membranes, they activate immune cells and proteins, causing cellular and humoral immunity. If the innate immune system is unable to destroy pathogens, the human adaptive immune system comes into play. The adaptive immune response relies on the recognition and activation process of innate immunity. Thus uncovering the regulation of the innate immune system is equally important for studying either its own or acquired immunity.
Drosophila resembles the human innate immune system in both molecular mechanisms and systemic regulation. While early work focused on microbial recognition and nuclear factor NF-κB signaling, Drosophila has recently been used to parse coordinated immune responses at the whole biological level in areas of study such as epithelial tissue-microbiota interactions, mechanisms of pathogens co-infection, and host immune evolution.
Fig.1 The responses and functions of the innate immune between Drosophila and human (Buchon et al.2014) Why Drosophila melanogaster?
Drosophila is a leading model organism for the study of immune pathways and regulation. Since the discovery of the conserved Toll signaling pathway and the humoral immune factor antimicrobial peptide (AMPs) in fruit flies, Drosophila has been widely used in vitro and in vivo platforms to study the molecular properties and cellular functions of human viruses and bacteria specific protein. In addition, Drosophila immunity studies provide a fundamental understanding of conserved host immunity against pathogens in postnatal animal species and how dysregulation of these processes leads to disease.
Extensive Immunity System Research Experience
CD BioSciences recommends Drosophila as a model or complementary model for studying human immune pathways, not only due to Drosophila shares approximately 75% genetic similarity with humans, but also because of the rapid and economical of Drosophila experiments without ethical implications. We can detect thousands of Drosophila mutants simultaneously, reducing the time and effort required to study your project. We have successfully completed research projects on mammalian enteric picornaviruses and human arboviruses, providing custom services for project design, project evaluation and interpretation of results.
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CD BioSciences Drosophila Center has the capacity to perform a variety of applications in immunology research. Our services go beyond this and our technology goes beyond this!
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Professionalism
We have built a professional platform and team with rich experience and cutting-edge knowledge to guarantee the scientific direction of the project.
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Personalized Service
We provide one-stop scientific solutions for innate immunity research to accelerate our clients' research speed.
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High Quality
We focus on the quality of our products and services. Optimal fruit flies ensure project results.
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Security
We strictly fulfill the confidentiality agreement to protect the privacy of our clients.
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Effective Price
We insist on win-win situation, providing the most comprehensive and intimate services at the best price.
Our Advantages
At CD BioSciences, we are committed to advancing bioscience technology and basic research using Drosophila. We provide a total solution for innate immunity research to our clients worldwide. With proven technologies and years of experience in the field of fruit fly, our PhD team conducts one-to-one technical consultancy and mechanistic studies to accelerate our clients' projects. Please feel free to contact us starting your private project customization.
References
- Hoffmann JA. (2003). The immune response of Drosophila. Nature, 426(6962), 33-38.
- Kounatidis I, et al. (2012). Drosophila as a model system to unravel the layers of innate immunity to infection. Open biology, 2(5), 120075.
- Buchon N, et al. (2014). Immunity in Drosophila melanogaster—from microbial recognition to whole-organism physiology. Nature reviews immunology, 14(12), 796-810.
- Imler JL. (2014). Overview of Drosophila immunity: a historical perspective. Developmental & Comparative Immunology, 42(1), 3-15.
- Troha K, et al. (2019). Methods for the study of innate immunity in Drosophila melanogaster. Wiley Interdisciplinary Reviews: Developmental Biology, 8(5), e344.
For research use only. Not intended for any clinical use.
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