Anti-D. melanogaster PRAS40 [p Thr356] Polyclonal Antibody

AKT1S1

Proline Rich Akt Substrate (PRAS40) is a 40 kDa substrate of Akt. Akt and PRAS40 can be found in the phosphoinositide 3 kinase (PI3K) pathway, which plays a role in glucose uptake, cell growth, and apoptosis inhibition. PRAS40 is a 14-3-3 binding protein that reacts with insulin, but whose precise function is not yet known. It may bind SH3 and WW domain containing proteins resulting in a change of function. Activated Akt phosphorylates PRAS40 on threonine 246. Mutation of PRAS40 threonine 246 has been shown to be apoptotic.

Rabbit

Polyclonal

IgG

Non-conjugated

Antigen Affinity-purified

Synthetic phospho-peptide corresponding to amino acid residues surrounding Thr356 conjugated to KLH.

Liquid

10 mM HEPES (pH 7.5), 150 mM NaCl, 100 μg per mL BSA and 50% glycerol.

WB

Drosophila melanogaster

Store at -20 °C or -80 °C.

Avoid freeze-thaw cycles.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.