Anti-D. melanogaster O-GlcNAc Monoclonal Antibody (RL2) - BSA Free

O-GlcNAc

Diffusion of metabolites and small non-nuclear molecules as well as active, mediated import of protein and export of protein and RNA through the nuclear envelope occurs through nuclear pore complexes or NPC's. NPC's contain up to 100 different polypeptides which have a combined mass of about 125 megadaltons. The channel available for passive transport through the NPC is about 9-10 nm in diameter while carrier mediated changes in the NPC result in a ~25 nm channel used for larger, actively transported molecules. Of the 100 polypeptides, at least 8 of these are O-linked N-acetylglycosamine-modified in mammalian cells. All of the mammalian O-linked glycoproteins contain multiple copies of phenylalanine, glycine dipeptide repeats dispersed throughout part of their sequence. Studies indicate that the NPC O-linked glycoproteins have a direct role in nuclear protein import.

Mouse

Monoclonal

IgG1

Non-conjugated

Protein A purified

Pore complex-lamina fraction purified from rat liver nuclear envelopes.

Liquid

PBS, pH 7.4

1.0 mg/mL

WB, ChIP, DB, ELISA, Flow, ICC/IF, IHC, IHC-P, IP

Drosophila melanogaster

Store at -20 °C or -80 °C.

Avoid freeze-thaw cycles.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.