Anti-D. melanogaster Histone H4 [Dimethyl Lys20] Polyclonal Antibody - BSA Free
- Catalog Number: CDDMAB-3121043
- Size: 100 μL; 50 μL; More Options
Target Information
| Target Names | HIST4H4 |
| Function | When K20 is di-methylated on H4, the downstream effect is silencing of genes. This modification is also necessary and sufficient for 53BP1 binding, which is a prerequisite for DNA repair, a highly conserved mechanism. H4K20me2 is associated with hypoacetylation, and inactivation of certain genes. NSD1 and Suv420h1/2 trigger the dimethylation of K20, but only after SET8 catalyzes the mono-methylation of the same lysine, indicating a complex regulation of this modification that can so seriously affect replication and stability of genomic information. |
Product Details
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugate | Non-conjugated |
| Purification Method | Immunogen affinity purified |
| Immunogen | Synthetic dimethylated peptide surrounding Lysine 20 of human Histone H4 [Swiss Prot P62805]. |
| Form | Liquid |
| Buffer | PBS, 30% Glycerol |
| Concentration | 0.53 mg/mL |
Usage
| Applications | WB, ChIP, DB, ICC/IF |
| Species Reactivity | Drosophila melanogaster |
Storage & Handling
| Storage Temp. | Store at -20 °C or -80 °C. |
| Handling | Avoid freeze-thaw cycles. |
| Limitations | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt. |
For research use only. Not intended for any clinical use.