Anti-D. melanogaster cup Polyclonal Antibody

cup

33934

Adapter protein that plays a central role in localization of transcripts in the oocyte and in young embryos. Maintains RNA targets in a repressed state by promoting their deadenylation and protects deadenylated mRNAs from further degradation. Binds to and recruits eIF-4E to the 3'-UTR of some mRNA targets which prevents interaction between eIF4E1 and eIF4G. This may contribute to translational repression but does not appear to be necessary for it to occur. Can promote translational repression independently of deadenylation and eIF4E1 binding. Required for correct localization of eIF4E1 in the developing oocyte. Required for translational repression of oskar (osk) mRNA. Also required for the translational repression of nanos (nos) mRNA. Promotes the accumulation of the germ plasm components osk, vas and stau at the posterior pole of the oocyte and is required for germ cell development. Represses orb positive autoregulatory activity which prevents premature activation of orb and ensures its accumulation specifically in the developing oocyte. In 0-1 hour embryos, forms a complex with me31B, cup, tral and pAbp which binds to various mRNAs including maternal mRNAs, and downregulates their expression during the maternal-to-zygotic transition.

Rabbit

Polyclonal

IgG

Non-conjugated

Protein A or G purified

Recombinant Drosophila melanogaster cup protein.

Liquid

Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

It differs from different batches. Please contact us to confirm it.

ELISA, WB

Drosophila melanogaster

Store at -20 °C or -80 °C.

Avoid freeze-thaw cycles.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.