Anti-D. melanogaster Cad99C Polyclonal Antibody

Cad99C

43528

Cadherin that functions in epithelial morphogenesis and the intestine epithelial immune response. Essential for female fertility. Regulates the length and organization of apical microvilli in developing follicle cells and salivary glands. Function in the follicle cell is essential for egg development as the microvilli secrete eggshell material such as the vitelline membrane. Acts at least in part by regulating the recruitment of the myosin ck to the follicle cell microvilli. Also required to regulate cell rearrangements during salivary tube elongation, possibly by modulating cellular adhesion between the apical surface and apical extracellular matrix during epithelial tube elongation. May also function in cellular adhesion during the development of other tubular epithelia such as the trachea. Possibly functions as an apical membrane determinant which acts in apical membrane expansion during salivary and tracheal epithelial tube elongation. In salivary gland development, this function is independent of the other apical membrane determinants crb and sas. Essential downstream component of a hh-signaling pathway which regulates the Duox-dependent gut epithelial immune response to bacterial uracil; required for endosome formation in the enterocyte and activating norpA-dependent Ca2+ mobilization, which are essential steps in the Duox-dependent production of reactive oxygen species (ROS) in response to intestinal bacterial infection.

Rabbit

Polyclonal

IgG

Non-conjugated

Protein A or G purified

Recombinant Drosophila melanogaster Cad99C protein.

Liquid

Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

It differs from different batches. Please contact us to confirm it.

ELISA, WB

Drosophila melanogaster

Store at -20 °C or -80 °C.

Avoid freeze-thaw cycles.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.